Melanotan I (MT-I)
FDA ApprovedMelanocortin Receptor Agonist
Community Research
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Synthetic analog of α-MSH that selectively targets MC1 receptors for melanin stimulation. FDA-approved as SCENESSE implant for erythropoietic protoporphyria (EPP). Research-grade injectable form enables flexible dosing versus the implant version.
Subcutaneous injection delivers peptide directly into systemic circulation. Selectively activates MC1R receptors to stimulate melanin production. Short half-life of approximately 30 minutes necessitates multiple daily dosing for sustained effect.
Molecular Data
α-melanocyte stimulating hormone analog Complex or non-standard sequence format
Research Indications
Stimulates melanin for deeper, longer-lasting tans with reduced UV requirements
Increased melanin density provides natural UV protection and reduces sunburn
Promotes uniform melanin distribution minimizing patchy tanning
FDA-approved indication for SCENESSE implant
Dosing Protocols
Subcutaneous injection with rotation between abdomen, thigh, and upper arm.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Loading phase | 0.25-0.5mg | 1-2x daily for 1-2 weeks | Subcutaneous |
| Maintenance | 0.25-0.5mg | 2-3x weekly | Subcutaneous |
Reconstitution Instructions
- 10mg Melanotan I vial
- Bacteriostatic water
- Insulin syringes
- Alcohol swabs
- 1 Clean vial top with alcohol pad
- 2 Add 2mL bacteriostatic water for 5mg/mL concentration
- 3 Gently swirl - do not shake
- 4 Solution should be clear and colorless
- 5 Store refrigerated for up to 4 weeks
Interactions
What to Expect
Side Effects & Safety
Common Side Effects
- Mild nausea
- Facial flushing
- Reduced appetite
- Increased mole/freckle pigmentation
Stop Signs - Discontinue if:
- Severe nausea/vomiting lasting >24 hours
- Rapid concerning mole/freckle changes
- Injection site infection signs
- Unusual skin reactions
- Allergic reaction symptoms
Quality Checklist
Good Signs
- Third-party HPLC testing confirming >98% purity
- Proper lyophilized powder storage
- Clear, colorless reconstitution
- Minimal side effects profile
Warning Signs
- Check expiration dates
Bad Signs
- Pre-mixed liquid solutions (degrade rapidly)
- Cloudy or discolored solution
Frequently Asked Questions
Is Melanotan I more selective than Melanotan II?
Yes. Melanotan I is more selective for MC1R (melanin production) and less active on MC4R (sexual function, appetite). This means MT-I causes tanning without the strong appetite suppression or sexual side effects of MT-II, making it better if tanning is the only goal.
How fast will I see results from Melanotan I?
Initial skin darkening appears within 3-7 days with UV exposure. Peak tanning is visible by week 2-4 with consistent low-dose UV tanning. The combination of MT-I plus 50% less UV exposure than normal achieves deep tans much faster than sun exposure alone.
Can I use Melanotan I without any UV exposure?
Melanotan I stimulates melanin production, so some pigment develops without sun exposure. However, UV exposure significantly enhances the effect—ideally low-dose tanning bed or sun exposure 1-2 hours after injection maximizes the tanning response.
Does Melanotan I cause mole changes like Melanotan II?
Less commonly than MT-II, but moles and freckles can darken and potentially enlarge with MT-I use. Regular skin monitoring via self-examination is important. The risk appears lower with MT-I than MT-II due to reduced MC3R/MC4R activation.
References
Disclaimer
This information is for educational and research purposes only. Consult a healthcare professional before use.